P-68  DISRUPTIVE EFFECTS OF 5-FLUOROURACIL ON THE CIRCADIAN CLOCK GENES: A POSSIBLE MOLECULAR MECHANISM OF ANTI-CANCER CHEMOTHERAPEUTIC-INDUCED CIRCADIAN RHYTHMIC DISTURBANCES

Ahmed Mohsen Hamdan, Hideyuki Terazono, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo

Department of Pharmaceutics, Clinical Division, Kyushu University, Japan

P-69  WITHDRAWN

P-70  CARF PLAYS A VITAL ROLE IN SENESCENCE AND APOPTOSIS, THE TWO MAIN TUMOR SUPPRESSION MECHANISMS IN HUMAN CELLS

Caroline Cheung, Kamrul Hasan, Navjot Shah, Sunil Kaul, Renu Wadhwa

Research Institute for Cell Engineering (RICE), National Institute of Advanced Industrial Science & Technology (AIST), Japan

P-71  EVALUATION OF ANTI-METASTATIC EFFECT OF GANODERMA LUCIDUM EXTRACTS ON CULTURED MAMMALIAN CANCER CELLS

Jarunya Ngamkham, Porntipa Picha, Mati Rienkitjakarn

Research Division, National Cancer Institute, Thailand

P-72  EFFECTS OF DIETARY MICROMELUM MINUTUM LEAVES ON THE METABOLIZING ENZYMES AND IN VITRO METABOLIC ACTIVATION OF CHEMICAL CARCINOGENS IN RATS

Nuntana Meesiripan, Anong Tepsuwan, Piengchai Kupradinum

Research Division, National Cancer Institute, Thailand

P-73  Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53

Eun Mi Choi, So Ra Kim, Eun Jeong Lee, Jeong A. Han

Department of Biochemistry and Molecular Biology, Kangwon National University College of Medicine, Korea

P-74  YS-5, A NOVEL NEOLIGNAN INDUCES APOPTOTIC CELL DEATH INVOLVING ACTIVATED SPINDLE ASSEMBLY CHECKPOINT IN HUMAN CANCER CELLS

Chiyen Chang¹, Chi-Yen Chang¹, Chia-Chi Lung¹, Yueh-Hsiung Kuo², Ching-Chuan Kuo¹, Kuo-Shun Hsu¹, Kai-Hsi Lu³, Chi-Hung Lin³, Jang-Yang Chang¹

¹Division of Cancer Research, National Health Research Institutes, Taiwan, ²Tsuzuki Institute for Tranditional Medicine, College of Pharmacy, China Medical University, Taichung, ³Institute of Microbiology and Immunology, National Yang Ming University, Taiwan

P-75  A HUMAN INTERVENTION TRIAL FOR IDENTIFICATION OF THE CHEMOPREVENTIVE PROPERTIES OF ISOTHIOCYANATES (ITCS) IN MUSTARD

Volker Mersch-Sundermann, Manuel Garcia-Kaeufer, Julia Prinzhorn, Stefan Schmitz, Evelyn Lamy

Institute of Environmental Health Sciences, University Medical Center Freiburg, Germany

P-76  Induction of Cell Death in Gemtuzumab Ozogamicin Resistant and CD33-Positive AML Cells by Enhancing Glutathione-Related Intracellular Oxidation

Shiro Jimi¹, Taichi Matsumoto², Tetsu Shirakawa³, Shuji Hara⁴, Yasushi Takamatsu², Kentaro Ogata³, Kazuo Tamura²

¹Department of Pathology, Fukuoka University, Japan, ²Department of Medicine, Fukuoka University, Japan, ³Department of Pharmaceutics, Fukuoka University, Japan, ⁴Department of Pharmaceutics, Fukuoka University, Japan

P-77  HETEROGENOUS NULCEAR RIBONUCLEOPROTEIN K (HNRNPK) IS A POTENTIAL TARGET OF METASTASIS

Ran Gao¹, Tetsuro Ishii¹, Sunil Kaul², Renu Wadhwa²

¹Graduate school of Life and Environmental Sciences, University of Tsukuba, Japan, ²National Institute of Advanced Industrial Science & Technology (AIST)

 YIA  P-78  FUNCTIONAL SIGNIFICANCE OF MOLECULAR INTERACTIONS BETWEEN THE ANTI-APOPTOTIC PROTEINS BCL-XL, BCL-2 AND MORTALIN

Nishant Saxena¹, Caroline T. Cheung², Bhupal G. Shreshtha², Tetsuro Ishii¹, Renu Wadhwa², Sunil C. Kaul³

¹Graduate School of Life and Environmental Studies, University of Tsukuba, Japan, ²Cell Proliferation Research Group, AIST Tsukuba Central 4, Japan, ³Cell Prolifeartion Research Group, AIST Tsukuba Central 4, Japan

P-79  MORTALIN AS A BIOMARKER FOR EARLY DETECTION OF CARCINOGENS IN WATER

Prasanna Vasudevan Iyengar¹, Nishant Saxena², Rumani Arora Singh¹, Sunil C. Kaul¹, Renu Wadhwa¹

¹Bioscience and Biotechnology, Tokyo Institute of Technology, Japan, ²National Institute of Advanced Industrial Science and Technology

P-80  EVALUATION OF ANTIPROLIFERATIVE PROPERTIES OF ASHWAGANDHA EXTRACT IN IMR 32 HUMAN NEUROBLASTOMA CELL LINE

Hardeep Kataria¹, Gurcharan Kaur¹, Renu Wadhwa², Sunil Kaul²

¹Department of Biotechnology, Guru Nanak Dev University, India, ²National Institute of Advanced Industrial Science and Tchnology, Japan

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